A minibus taxi carrying pupils overturned near Dutywa on Friday night killing a driver and a schoolgirl.
Other pupils were rushed to a nearby health facility and later transferred to Butterworth Hospital.
According to police spokesman Captain Jackson Manatha and health provincial spokesman Sizwe Kupelo, the pupils were travelling from a school match in Ngcobo to Willowvalle.
"The Toyota quantum ferrying pupils from a high school in Ngcobo to Willowvale had accident near Mbewuleni Village, Dutywa, along the R408 road. The accident took place on Friday at about 9pm.
"A female pupil, age about 17 and a 27-year-old taxi driver were fatally wounded. Other 12 learners were rushed to Butterworth hospital."
The taxi did not collide with any other vehicle. The cause of the accident was still unknown at at the time of publishing.
Dutywa Police were busy investigating the cause of the accident, said Manatha.