Netcare 911 spokesperson Shawn Herbst said a man believed to be an illegal miner was shot dead after he allegedly pointed a gun at police.
Herbst said multiple other zama-zamas were injured trying to escape.
Police spokesperson Lirandzu Themba confirmed the incident, saying the miners pushed back after the raid.
Some were arrested.
According to Themba, police minister Bheki Cele joined a team consisting of tactical response, Hawks, Crime Intelligence, the K-9 unit, Gauteng traffic police, Sibanye-Stillwater mining security and private security to tackle the illicit operations.