Overall, Vingegaard leads Pogacar of Slovenia by 3:34 and Britain's Geraint Thomas by 8:13 ahead of Sunday's final stage, a largely processional ride from La Defense to the Champs Elysees in Paris.
Vingegaard set the foundations for his victory in the 10th stage after attacking Pogacar relentlessly with his teammates before the last climb up to the Col de Granon, where the Slovenian cracked and lost the yellow jersey.
Vingegaard moved closer to victory when he prevailed in the final mountain stage at Hautacam after Pogacar's all-in strategy failed to pay off, on the same climb where Bjarne Riis, the only Danish winner of the Tour, had produced one of the most stunning performances ever seen in the race.
Riis later admitted to doping to win the 1996 Tour de France, but retained his title for legal reasons.
Vingegaard's upcoming triumph seals an awe-inspiring three weeks by Jumbo-Visma as the formidable all-rounder Van Aert added three and their domestique Christophe Laporte one to the Dane's two stage victories.
Van Aert will also win the green jersey for the points classification as Jumbo-Visma take three distinctions home with Vingegaard also prevailing in the mountains classification.